The granulocyte-angiotensin system. Angiotensin I-converting activity of cathepsin G.

Angiotensin Converting Enzyme in Sarcoidosis

Chemistry of a human monocyte-derived cell line (U937): identification of the angiotensin I-converting activity as leukocyte cathepsin G.

Angiotensin-converting enzyme, a dipeptidyl carboxypeptidase, catalyzes the conversion of angiotensin I to the vasoactive peptide angiotensin II. The finding of angiotensin-converting enzyme in dexamethasone-stimulated cultured monocytes and alveolar macrophages prompted the examination of a human monocyte-like cell line (U937) for angiotensin I-converting activity. Conversion of angiotensin I ...

Angiotensin I converting enzyme.

• Interest in particular biologically active substances waxes and wanes. Investigators rush into a newly opened field, solve a few problems, and frequently raise more; then they rush out to follow more promising developments elsewhere. However, interest in angiotensins generally has persisted and increased. Observation of the actions of angiotensins has led to the study of enzymes involved in t...

New Perspectives in the Renin-Angiotensin-Aldosterone System (RAAS) I: Endogenous Angiotensin Converting Enzyme (ACE) Inhibition

Angiotensin-converting enzyme (ACE) inhibitors represent the fifth most often prescribed drugs. ACE inhibitors decrease 5-year mortality by approximately one-fifth in cardiovascular patients. Surprisingly, there are reports dating back to 1979 suggesting the existence of endogenous ACE inhibitors, which endogenous inhibitory effects are much less characterized than that for the clinically admin...

Two loci affect angiotensin I-converting enzyme activity in baboons.

Serum LDL cholesterol (LDLC) concentrations and ACE activities are risk factors for the development of cardiovascular disease (CVD). However, the relationship between ACE and CVD susceptibility, and possible mechanisms of action, is controversial. With data on 622 pedigreed baboons, we used statistical genetic methods to determine the mode of inheritance of ACE activities and its relationship t...